Director, Clinical Supply Chain


The mission of Centessa Pharmaceuticals plc (Nasdaq: CNTA) is to deliver consequential new medicines to patients. The Centessa family includes ten wholly owned, highly specialized companies, with drug discovery and development programs in diverse therapeutic areas. The company’s organizational structure and approach combine the agility and sense of urgency typical of start-up companies with the scale and diversification typical of larger R&D organizations.


Palladio Bioscience, a Centessa Company, is in Phase 3 development for the treatment of autosomal dominant polycystic kidney disease (ADPKD), one of the most common, serious genetic diseases in humans. It is the 4th leading cause of kidney failure in the United States and is a life-threatening, chronic and progressive disease. The disease carries a significant financial and emotional burden, affecting entire families with no know cure for PKD.

We are looking for a Director, Clinical Supply Chain that will be responsible for the management of all drug substance, bulk and final packaged drug product supply as well as ensure proper allocation of drug product as needed across assigned programs.  Responsible and accountable for establishing the timelines for bulk manufacturing and final product packaging across assigned programs.


  • Work within a team to provide global supply chain support of all clinical programs and non-clinical logistical needs.
  • Monitor of international and domestic shipments
  • Create or facilitate the creation of necessary documentation to allow for customs clearance.
  • Monitor shipments and ensure that issues with transit are proactively identified and resolved quickly and escalated as needed
  • Vendor management to track performance or highlight process improvement areas
  • Manage and maintain safety stock and working stock levels appropriately. Creation of KPIs and reporting is required on a frequent basis
  • Highlight any concerns related to material readiness or material availability
  • Maintain key vendor relationships and serve as the key point of contact
  • Identify supply gaps and address as needed
  • Provide sourcing support for materials needed to execute manufacturing and packaging runs
  • Manage fulfillment and materials requests, maintain relevant databases
  • Manage necessary CMO inventory
  • Responsible for demand planning activities in conjunction with project management and clinical operations


  • Bachelor’s degree in a scientific, business, or related discipline required with a minimum of 10+ years relevant experience in pharmaceutical and/or clinical drug development with experience in planning, scheduling, coordination and processing of clinical supply activities, or the equivalent
  • Experience and strong working knowledge of cold chain shipping equipment and methodologies as well as international shipping requirements (such as IATA packaging instructions)
  • Proficiency in Microsoft (MS) Office software including Word, Excel, PowerPoint
  • Ability to travel to company offices, sites, vendors, and meetings as required
  • Strong project planning/management expertise
  • Excellent written and verbal communication, strong problem-solving ability, and attention to detail and quality
  • Strong team player, open to challenge, as well as flexible, pragmatic, proactive
  • Light work that includes moving objects up to 10 pounds
  • Willing to travel domestically and/or internationally up to 15%

POSITION: Full-Time, Exempt

EEOC Statement: Centessa Pharmaceuticals and its family of company's  believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law

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