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Patrick Yue MD

Senior Vice President Clinical Development Innovative Medicines

Dr. Patrick Yue is Senior Vice President of Clinical Development, Innovative Medicines. Prior to joining Centessa, Dr. Yue was Vice President of Clinical Science  at Global Blood Therapeutics, where he oversaw four development programs, including  voxelotor (Oxbryta), a treatment for sickle cell disease.  Dr. Yue has spent 12 years in the biotech/pharmaceutical industry, taking on roles of increasing responsibility at Gilead, Portola, Alexion, and Pfizer.  Prior to joining the industry, Dr. Yue completed his medical internship and residency at Beth Israel Deaconess Medical Center and received specialty training in cardiovascular medicine at Stanford University School of Medicine. Dr. Yue holds a BS in Biology and Chemistry from the California Institute of Technology and an MD from Washington University School of Medicine.

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SerpinPC

Overview
SerpinPC is a subcutaneously administered novel inhibitor of APC being developed as a potential treatment for hemophilia, regardless of severity or inhibitor status, and may also prevent bleeding associated with other bleeding disorders. Centessa is advancing the registrational program for SerpinPC in hemophilia B, which includes a set of clinical studies with multiple components. PRESent-5, initiated in late 2022, is an observational feeder study to collect prospective observational data for minimum defined periods before switching to dosing subjects in the interventional studies. The interventional studies include PRESent-2 (moderately severe to severe hemophilia B without inhibitors, and severe hemophilia A with and without inhibitors) and PRESent-3 (hemophilia B with inhibitors). Additional information on the trials can be accessed at www.clinicaltrials.gov  (NCT05605678, NCT05789524, NCT05789537). SerpinPC is an investigational agent that has not been approved by the FDA or any other regulatory authority.

Reason to Believe in Target
Human Genetics Support

Epidemiology
~20,000 persons with hemophilia in the United States
450,000 estimated global prevalence
Disease

Hemophilia B