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Summary and Pipeline

We aim to discover and develop medicines that are transformational for patients

We are developing potential best-in-class orexin receptor 2 (OX2R) agonists intended to be orally administered for the treatment of sleep-wake disorders including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH), and excessive daytime sleepiness (EDS) in neurological, neurodegenerative, and neuropsychiatric conditions. We anticipate that our orexin agonists may have utility in treating impaired attention, cognitive deficits, fatigue and other symptoms. We also have an early-stage immuno-oncology program focused on our LockBody® technology platform.

 

Centessa’s team is made up of pioneers in their fields working to advance our core programs. Read more on the inspiring stories of the continuing journeys from vision to transformational medicines below.

Realizing Our Vision

We are working to discover unique opportunities to potentially address key medical needs

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Orexin Receptor 2 Agonist Program

Trained as a bioengineer, Dr. Mario Alberto Accardi, President of the Centessa Orexin Program, saw the opportunity to use structure-based drug design to disrupt the conventional approach to treating sleep-wake disorders, EDS, impaired attention, cognitive deficits, fatigue and other symptoms.

 

Click below to learn more about our orexin receptor 2 agonist program for sleep-wake disorders and other conditions.

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LockBody® Technology Platform in Oncology

Dr. William Finlay, President of the Centessa LockBody Program and a widely published expert on antibody engineering, developed the LockBody® technology platform with the goal to redefine immuno-oncology treatment for patients with cancer.
 

Click below to learn more about our novel LockBody® platform in oncology.  

Pipeline

Our Most Advanced Potential Best-in-Class / First-in-Class Medicines for Patients 

Asset

Disease/Condition

Mechanism

Pre-clinical

Phase 1

Phase 2

Registrational

ORX750

Narcolepsy Type 1 (NT1)

OXR2 Agonist
ORX750
Narcolepsy Type 2 (NT2)
OXR2 Agonist
ORX750
Idiopathic Hypersomnia (IH)
OXR2 Agonist

ORX142

Neurological & Neurodegenerative Disorders

OXR2 Agonist

ORX489

Neuropsychiatric Disorders

OXR2 Agonist

Centessa also has multiple early-stage assets including the LockBody® Technology Platform.

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Centessa’s mission is to discover and develop medicines that are transformational for patients. View our Expanded Access Policy for investigational medical products.

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