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Samarth Kulkarni PhD

Chief Executive Officer

CRISPR Therapeutics

Dr. Samarth Kulkarni, PhD, has served as CRISPR Therapeutics’ Chief Executive Officer since 2017. He has significant expertise in strategy and operations in biotech and a wide range of related cutting-edge therapeutic technologies. He joined CRISPR in 2015 in the early stages of the company as Chief Business Officer and was appointed to President and Chief Business Officer before becoming Chief Executive Officer.

Prior to joining CRISPR Therapeutics, Sam was a Partner at McKinsey & Company, where he had a leading role in the pharmaceutical and medical products practice. While at McKinsey, he co-led the biotech practice, where he focused on strategy and operations and led initiatives in areas such as personalized medicine and immunotherapy.

Sam also serves on the Board of two precision oncology companies, Black Diamond Therapeutics and Repare Therapeutics, and on the board of the Emerging Companies Section of the Biotechnology Innovation Organization (BIO). Previously, Sam served as the Chairman of the Board of Directors of Casebia Therapeutics, a joint subsidiary formed by CRISPR Therapeutics and Bayer.

Sam received a PhD in Bioengineering and Nanotechnology from the University of Washington and a BTech from the Indian Institute of Technology. While at the University of Washington, he conducted research on the delivery of biological drugs and in the field of molecular diagnostics.

Sam has authored several publications in leading scientific and business journals.

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SerpinPC

Overview
SerpinPC is a subcutaneously administered novel inhibitor of APC being developed as a potential treatment for hemophilia, regardless of severity or inhibitor status, and may also prevent bleeding associated with other bleeding disorders. Centessa is advancing the registrational program for SerpinPC in hemophilia B, which includes a set of clinical studies with multiple components. PRESent-5, initiated in late 2022, is an observational feeder study to collect prospective observational data for minimum defined periods before switching to dosing subjects in the interventional studies. The interventional studies include PRESent-2 (moderately severe to severe hemophilia B without inhibitors, and severe hemophilia A with and without inhibitors) and PRESent-3 (hemophilia B with inhibitors). Additional information on the trials can be accessed at www.clinicaltrials.gov  (NCT05605678, NCT05789524, NCT05789537). SerpinPC is an investigational agent that has not been approved by the FDA or any other regulatory authority.

Reason to Believe in Target
Human Genetics Support

Epidemiology
~20,000 persons with hemophilia in the United States
450,000 estimated global prevalence
Disease

Hemophilia B