team Karen Anderson

Karen Anderson

Chief People Officer

Karen Anderson joined Centessa in November 2022 as Chief People Officer. Karen has over 25 years of experience in human resources roles spanning the biotechnology/pharmaceutical, technology and healthcare industries. Prior to joining Centessa, Karen was Chief Human Resources Officer at Mimecast Limited. Previously, she was Senior Vice President and Chief Human Resources Officer at Alnylam Pharmaceuticals where she supported the strategic direction and business growth from a few hundred employees to more than 1,000 employees in 16 global legal entities. Karen was also Vice President of Human Resources at Pfizer, supporting the Commercial business unit in both developed and emerging markets. Earlier in her career she was responsible for compensation, benefits and systems for Bayer Canada before becoming the Global Human Resources Director for Baxter where she had a strong focus on mergers and acquisitions.

Karen has a Masters in Organization Development and Psychology. 

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SerpinPC

Overview
SerpinPC is a subcutaneously administered novel inhibitor of APC being developed as a potential treatment for hemophilia, regardless of severity or inhibitor status, and may also prevent bleeding associated with other bleeding disorders. Centessa is advancing the registrational program for SerpinPC in hemophilia B, which includes a set of clinical studies with multiple components. PRESent-5, initiated in late 2022, is an observational feeder study to collect prospective observational data for minimum defined periods before switching to dosing subjects in the interventional studies. The interventional studies include PRESent-2 (moderately severe to severe hemophilia B without inhibitors, and severe hemophilia A with and without inhibitors) and PRESent-3 (hemophilia B with inhibitors). Additional information on the trials can be accessed at www.clinicaltrials.gov  (NCT05605678NCT05789524NCT05789537). SerpinPC is an investigational agent that has not been approved by the FDA or any other regulatory authority.

Reason to Believe in Target
Human Genetics Support

Epidemiology
~20,000 persons with hemophilia in the United States
450,000 estimated global prevalence
Disease

Hemophilia B